Oryzias latipes (JAPANESE MEDAKA) AS GENETIC MODEL TO STUDY CAUSATIVE GENES OF EPILEPSY DISEASE: AN IN-SILICO APPROACH

Epilepsy is a chronic neurological disorder that has affected around 50-70 million people worldwide. Various animal models have previously been used in epilepsy research. To expand the knowledge of disease, new model suggested to be explored considering genetic and phenotypic heterogeneity contributes complexity disease. This study was undertaken analyze 14 causative genes disease Japanese medaka (Oryzias latipes), humans, established this which zebrafish (Danio rerio) by assessing variation using MEGA X predicting functional motif secondary structure proteins PROSITE GORIV respectively. Results from analysis showed lowest percentage conserved 60%.50% were found more than comparison human. The motifs present all same humans. All structures predicted contain alpha helix, extended strand, random coil. In conclusion, it can inferred could reliable for